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pandora jewelry For example, it has been proposed that pre eclampsia is the consequence of a maternal immune reaction against paternal antigens expressed in the placenta and that this reaction might result in defective trophoblast invasion and subsequent placental dysfunction. The lower risk of pre eclampsia among multiparous women has been attributed to desensitisation after exposure to paternal antigens in the placenta during previous pregnancies.1 2 The lower risk has also been attributed to smoother trophoblastic invasion after modification of maternal spiral arteries during the first pregnancy.3We hypothesised that pre eclampsia is more common in first pregnancies because women who experience pre eclampsia during their first pregnancy, whom might have an increased risk for genetic or environmental reasons, might decide not to take further risks and have no more pregnancies. In addition, subfecundity has been associated with a higher risk of pre eclampsia.4 Thus an underlying disorder might result in both pre eclampsia in the first pregnancy and subsequent infertility.Most previous studies included relatively small cohorts of pregnancies without prospective follow up of women from the beginning of their reproductive history.1 5 We used a large population based cohort to investigate the association between parity and the risk of pre eclampsia, before and after adjustment for potential selection bias.MethodsStudy populationThe Swedish Medical Birth Register is a population based registry that includes more than 98% of all births in Sweden.6 Starting with the first antenatal visit, normally at 8 12 weeks’ gestation, information is prospectively collected on maternal demographic data, reproductive history, pregnancy, and birth characteristics pandora jewelry.

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